Regasta (50mg) 10 Tablets

Regasta (50mg) 10 Tablets

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  • Manufacturer GETZ PHARMACEUTICALS (PVT.) LTD.
  • Generic Name

    Itopride 50mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Laboratory Screening
  • Description

    Itopride's primary mechanism of action involves its ability to regulate gastrointestinal motility by acting on specific receptors in the digestive system. It is a mixed agonist of dopamine type-2 (D2) and antagonist of serotonin type-4 (5-HT4) receptors. By stimulating D2 receptors, itopride inhibits the release of acetylcholine, which reduces gastrointestinal motility. In contrast, its blockade of 5-HT4 receptors enhances gastrointestinal motility by increasing acetylcholine release. This dual action helps regulate the contractions of the stomach and intestines, improving gastric emptying and reducing symptoms associated with gastrointestinal disorders.

  • Ingredients

    Itopride 50mg

  • Drug Class

    Prokinetic agent

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Itopride 50mg Tablet:

    • Used for treating Gastroesophageal Reflux Disease (GERD) by speeding up stomach emptying.
    • Used to alleviate symptoms like heartburn, nausea, and indigestion.
    • Used for treating functional dyspepsia, improving digestion and reducing stomach pain.
    • Used to enhance gastrointestinal motility, ensuring food moves efficiently through the digestive tract.
    • Used in the treatment of diabetic gastroparesis to stimulate gastric emptying.
    • Used for managing gastrointestinal disorders with effective control of symptoms.
    • Used to prevent and treat gastric ulcers by regulating gastric acid secretion.
    • Used to support overall digestive health and comfort.
  • Dosage

    Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

    • For the treatment of gastrointestinal disorders such as nausea, vomiting, and diarrhea, the standard dosage is 50mg three times a day.
    • For the treatment of gastrointestinal symptoms resulting from chemotherapy or radiation therapy, such as nausea, vomiting, and diarrhea, the recommended dosage is 50mg four times a day.
    • Itopride Hydrochloride 50mg may also be used to treat other conditions, such as gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and gastroparesis. It's crucial to follow your doctor's instructions regarding dosage for these conditions, as it may vary.
    • It's worth noting that dosage instructions may vary from person to person, depending on the severity of their condition. To ensure the safest and most effective treatment, it's recommended to consult a medical professional or a pharmacist before taking Itopride Hydrochloride 50mg.
  • In case of Overdose

    In the case of an overdose of Itopride 50mg Tablets, it is important to act swiftly. The initial symptoms may include severe nausea, dizziness, and an increased heart rate. Seek medical assistance immediately and provide the healthcare professional with details of the overdose, including the number of tablets consumed. Prompt treatment can help manage the adverse effects and ensure the patient's well-being. It is crucial to take appropriate measures to prevent overdoses and keep medications out of reach of children.

  • Missed Dose

    In the case of a missed dose of Itopride 50mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to remind you to take your medication at the prescribed times.

  • How To Use

    To take Itopride 50mg Tablet, swallow the tablet whole with a glass of water, preferably before a meal, as directed by your healthcare professional, typically twice a day (before breakfast and dinner) or as prescribed based on your medical condition.

  • When Not to Use

    Following are the conditions/situations when Itopride 50mg Tablet should not be used:

    • Must be avoided in individuals with a known allergy to Itopride or any of its ingredients.
    • Not suitable for patients with gastrointestinal bleeding or those who have a blockage in the digestive tract.
    • Contraindicated in individuals with severe kidney or liver disease.
    • Should not be used in patients with a history of epilepsy or seizures.
    • Not recommended for individuals with a type of tumor that releases excess gastrin (a hormone), known as gastrinoma.
    • Avoid using if the patient has an artificial pacemaker or other implanted medical devices.
    • Not suitable for individuals with a known condition called pheochromocytoma (a rare adrenal gland tumor).
  • Side Effects

    The side effects of Itopride 50mg Tablet may include:

    • Diarrhea
    • Dry mouth
    • Fatigue
    • Headache
    • Dizziness
    • Constipation
    • Abdominal pain
  • Precautions & Warnings

    Following are the precautions and warnings for Itopride 50mg Tablet:

    • Not recommended for individuals with known allergies to Itopride or similar medications.
    • Patients with kidney or liver disease should use with caution, as dosage adjustments might be necessary.
    • May cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
    • Alcohol consumption should be avoided or limited while taking this medication.
    • Not suitable for children and adolescents under 18 years of age.
    • Elderly patients may be more sensitive to the side effects, so close monitoring is advised.
    • Itopride may interact with other medications; inform your doctor about all the medicines you are taking.
    • Consult your doctor immediately if you experience any severe or persistent side effects.
  • Drug Interactions

    Following are the drug interactions for Itopride 50mg Tablet:

    • Itopride may interact with other dopamine antagonists, such as metoclopramide, leading to increased risk of extrapyramidal symptoms.
    • Concomitant use with anticholinergic drugs can reduce the effectiveness of Itopride.
    • Itopride can increase the absorption of certain medications, including antibiotics like erythromycin and antifungals like ketoconazole.
    • The absorption of Itopride may be reduced when taken with proton pump inhibitors (PPIs) like omeprazole.
    • Caution is advised when using Itopride with drugs that prolong QT interval, as it may increase the risk of cardiac arrhythmias.
    • Itopride may increase the effects of anticoagulants, such as warfarin, requiring close monitoring of coagulation parameters.
    • Interactions with other prokinetic agents like domperidone may increase the risk of adverse effects.
  • Food Interactions

    Following are the food interactions for Itopride 50mg Tablet:

    • Avoid consuming grapefruit and grapefruit juice as they may interfere with the metabolism of Itopride, leading to increased drug levels in the body and potentially causing more side effects.
    • Alcohol intake should be minimized or avoided as it can increase the risk of adverse effects, particularly in the central nervous system, such as dizziness and drowsiness.
    • High-fat meals can delay the absorption of Itopride, possibly reducing its effectiveness, so it is best to take the medication on an empty stomach or as advised by your doctor.
    • Caffeine-rich foods and beverages like coffee, tea, or energy drinks may exacerbate gastrointestinal symptoms and should be consumed in moderation.
    • Spicy foods can irritate the digestive system and potentially worsen gastritis or acid reflux symptoms, so it is advisable to limit their consumption.
    • Itopride may interact with dairy products, particularly milk, as calcium can form insoluble complexes with the drug, reducing its absorption. Consider separating milk intake from medication by a few hours.
    • Avoid excessive consumption of sugary foods and beverages as they can contribute to gastrointestinal issues and potentially interfere with the medication's effectiveness.
    • Staying well-hydrated is essential, but excessive fluid intake close to medication timing may dilute stomach acids, affecting Itopride's absorption.
  • Storage/Disposal

    Itopride 50mg Tablets should be stored in a secure and dry location, ideally in a medicine cabinet, at room temperature, which is typically between 20-25°C (68-77°F). Protect the tablets from light and moisture by keeping them in their original packaging, ensuring the container is tightly sealed. It's crucial not to store them in the bathroom due to its humidity. Always check the expiry date before taking any medication, and if the tablets have passed their expiration, do not use them and dispose of them carefully. To safely dispose of Itopride tablets, do not flush them or throw them into the trash; instead, consult your pharmacist or a healthcare professional for guidance on proper disposal methods in your area, ensuring they are kept out of the reach of children and pets.

  • Quick Tips, if any

    Following are the quick tips for Itopride 50mg Tablet:

    • Take the tablet as directed by your doctor, typically 30 minutes before meals.
    • Swallow the tablet whole with a glass of water, do not crush or chew.
    • Avoid alcohol while taking this medication as it may worsen side effects.
    • If you experience dizziness, exercise caution when driving or operating machinery.
    • Inform your doctor about all medications you are taking to prevent potential interactions.
    • Store the tablets in a cool, dry place, away from direct sunlight.
    • Do not share this medication with others, even if their symptoms are similar.
  • Laboratory Screening

    Itopride Hydrochloride 50mg is a medication used to treat symptoms of heartburn and stomach ulcers. While every individual will have different lab test requirements, it is always best to follow the advice of a medical professional. Thus, it is essential to adhere to the prescribed dosage and frequency. However, there are a few laboratory investigations that require regular monitoring while taking Itopride Hydrochloride 50mg. These investigations include:

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