Lukodermine (10mg) 30 Tablets

Methoxsalen's primary mechanism of action involves its ability to intercalate into DNA and induce photochemical reactions upon exposure to ultraviolet (UV) light, specifically in the UVA range. By intercalating into DNA, methoxsalen forms covalent bonds with pyrimidine bases, primarily thymine. When exposed to UVA radiation, the methoxsalen-DNA complex undergoes a photochemical reaction, forming a variety of photoproducts, including monoadducts, inter• and intrastrand crosslinks, and DNA-protein crosslinks. These photoproducts lead to DNA damage, primarily in the form of cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). The formation of these photoproducts induces a cellular response, triggering DNA repair mechanisms, cell cycle arrest, and apoptosis in rapidly dividing cells, particularly those involved in conditions like psoriasis and vitiligo. This process is believed to be responsible for the therapeutic effects of methoxsalen when used in combination with controlled UVA exposure.

Psoralen

Tablet

The following are the uses of Methoxsalen 10mg Tablet:

• Used for treating psoriasis, a skin condition characterized by red, itchy, and scaly patches.
• Used for managing severe, treatment-resistant cases of psoriasis.
• Used for treating a type of skin condition called vitiligo, where the skin loses its color in patches.
• Used for repigmenting the skin in vitiligo patients by increasing sensitivity to light.
• Used for enhancing the effectiveness of phototherapy, a treatment using ultraviolet light.
• Used for treating a rare inherited disorder called xeroderma pigmentosum, which causes extreme sensitivity to UV light.
• Used for managing certain skin conditions in combination with controlled exposure to sunlight or ultraviolet light.

In the case of an overdose of Methoxsalen 10mg Tablets, it is important to act promptly. Symptoms may include severe nausea, vomiting, and photosensitivity. If you suspect an overdose, seek medical advice immediately. Treatment may involve managing symptoms and providing supportive care. Prompt action can help mitigate potential adverse effects, ensuring the best possible outcome. It is crucial to take appropriate measures to prevent accidental overdoses and keep medications out of reach of children.

In the case of a missed dose of Methoxsalen 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may recommend adjusting your dosing schedule or provide specific instructions to ensure the treatment remains effective.

To take Methoxsalen 10mg Tablet, swallow the tablet whole with a glass of water, preferably on an empty stomach, following the dosage instructions provided by your healthcare professional, typically 1 to 3 hours before UV light exposure as part of a photochemotherapy treatment.

Following are the conditions/situations when Methoxsalen 10mg Tablet should not be used:

• Should not be used in individuals with a known hypersensitivity or allergy to Methoxsalen or any of its ingredients.
• Contraindicated in patients with a history of sunlight or UV light sensitivity.
• Not recommended for individuals with systemic lupus erythematosus (SLE).
• Should be avoided in patients with a history of skin cancer or those at high risk for developing skin cancer.
• Contraindicated in patients with porphyria, a disorder affecting the skin and nervous system.
• Not suitable for individuals with a history of severe sunburn or blistering reactions to sunlight.
• Should not be used in patients with certain eye conditions like cataracts or macular degeneration.
• Avoid use in patients with liver or kidney disease, as it may affect drug metabolism.
• Not recommended for children under 12 years of age due to increased sensitivity.

The side effects of Methoxsalen 10mg Tablet may include:

• Nausea and vomiting.
• Itching or burning sensation.
• Redness and swelling of the skin.
• Blistering or peeling of the skin.
• Increased sensitivity to sunlight.
• Headaches and dizziness.
• Skin rash or hives.
• Changes in skin pigmentation.

Following are the precautions and warnings for Methoxsalen 10mg Tablet:

• Do not use this medication if you are allergic to Methoxsalen or any of its ingredients.
• Methoxsalen increases sensitivity to sunlight, so avoid excessive exposure to sunlight and UV rays. Wear protective clothing and use sunscreen when outdoors.
• Patients with a history of skin cancer or those at high risk should exercise caution and consult a healthcare professional before use.
• It may cause skin reactions, including severe sunburn, blisters, or skin discoloration. Discontinue use and seek medical advice if these occur.
• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.
• Pregnant and breastfeeding women should consult their doctor before taking Methoxsalen, as it may pose risks to the fetus or infant.
• Keep out of reach of children and pets. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Methoxsalen 10mg Tablet:

• Avoid concurrent use with other photosensitizing agents like thiazide diuretics, tetracyclines, and sulfonamides, as it may increase the risk of severe sunburn.
• Methoxsalen can increase the effects of warfarin and other anticoagulants, requiring close monitoring of INR values.
• Concomitant use with other immunosuppressants may lead to increased immunosuppression and potential infections.
• It may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• The risk of seizures may increase when combined with medications that lower the seizure threshold, such as certain antidepressants and antipsychotics.
• Caution is advised when using with St. John's Wort, as it may decrease Methoxsalen's effectiveness.
• Avoid alcohol consumption during treatment, as it may increase the risk of adverse effects and skin reactions.

Following are the food interactions for Methoxsalen 10mg Tablet:

• Avoid excessive exposure to sunlight, especially during peak hours (10 am to 4 pm), as this drug increases skin sensitivity to UV rays, raising the risk of severe burns.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the drug's effects, leading to potential skin reactions.
• Avoid excessive alcohol consumption, as it can increase skin sensitivity and the risk of severe sunburn.
• Certain foods rich in vitamin A, like liver, fish liver oils, and certain supplements, should be consumed in moderation, as high vitamin A levels can increase skin sensitivity.
• Fatty foods may affect the absorption of Methoxsalen, so it's best to follow the doctor's advice regarding dietary restrictions.
• Avoid photodynamic foods like figs, carrots, celery, and parsley, as they can increase skin sensitivity to sunlight.
• Inform your doctor if you have a diet rich in vitamin D or calcium supplements, as these may interact with the medication.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions and interactions with Methoxsalen.

Methoxsalen 10mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and heat. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. It is crucial not to store them in the bathroom or kitchen, as these areas may have high humidity levels that can degrade the medication. Always check the expiration date regularly, and properly dispose of any unused or expired tablets. Do not dispose of them by flushing or pouring them down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Ensure that the medication is kept out of the sight and reach of children and pets to prevent accidental consumption.

Following are the quick tips for Methoxsalen 10mg Tablet:

• Always take the medication as directed by your healthcare professional.
• Ensure you understand the dosage instructions and never exceed the prescribed amount.
• Schedule your doses at consistent times each day to maximize effectiveness.
• Avoid exposure to sunlight and UV rays, especially after taking the medication.
• Wear protective clothing and sunscreen when going outdoors during treatment.
• Store the tablets in a secure place, away from children and pets.
• Inform your doctor about any other medications or supplements you are taking.