Glio (4mg) 20 Tablets

Glimepiride 4mg Tablet primarily works by stimulating the release of insulin from the pancreatic beta cells. It belongs to the sulfonylurea class of drugs and selectively binds to sulfonylurea receptor 1 (SUR-1) subunits on pancreatic beta cells, promoting insulin secretion. This mechanism is dependent on the presence of functional beta cells in the pancreas. The increased insulin release helps lower blood glucose levels by enhancing the uptake of glucose by peripheral tissues, such as muscles and adipose tissue, and reducing glucose production in the liver. Glimepiride's action is rapid, leading to a prompt decrease in blood glucose after administration.

Glimepiride 4mg

Sulfonylurea.

Tablet

The following are the uses of Glimepiride 4mg Tablet:

• Used for treating type 2 diabetes when diet and exercise alone are not effective in controlling blood sugar levels.
• Used to help lower blood glucose levels and manage insulin resistance.
• Used to improve glucose tolerance and reduce the risk of diabetic complications.
• Used to stimulate the release of insulin from the pancreas, aiding in glucose metabolism.
• Used to control hyperglycemia and prevent long-term diabetes-related health issues.
• Used to enhance the body's response to insulin, promoting better blood sugar control.
• Used as part of a comprehensive diabetes management plan to improve overall health.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• The standard starting dose of Glimepiride for managing type 2 diabetes is 1mg to 4mg once daily.
• It is usually prescribed to be taken before breakfast or with the first meal of the day.
• Glimepiride reaches its maximum effect within 1–2 hours after administration, and it has a half-life of around 2–4 hours.
• In case of any severe health issues, consult a doctor for the right dosage as you should not self-medicate.

In the case of an overdose of Glimepiride 4mg Tablets, it is important to recognize the potential severity of the situation. Symptoms may include excessive sweating, tremors, and confusion. Immediate action should be taken by contacting emergency medical services or seeking the nearest emergency room. Prompt treatment can help manage the overdose and prevent potential complications, such as severe hypoglycemia, which can be life-threatening if left untreated. Quick response and professional medical care are essential.

In the case of a missed dose of Glimepiride 4mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to adjust your dosage or provide specific instructions to ensure you receive the correct amount of medication.

To take Glimepiride 4mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your doctor, usually with breakfast or the first main meal of the day.

Following are the conditions when Glimepiride 4mg Tablet should not be used:

• Must not be taken if you have a known allergy to Glimepiride or any other sulfonylurea medications.
• Not suitable for individuals with type 1 diabetes mellitus or diabetic ketoacidosis.
• Contraindicated in patients with severe kidney or liver impairment.
• Should not be used if you have a severe infection, serious injury, or are experiencing surgery and related stress.
• Not recommended for individuals with a history of hypersensitivity reactions to sulfonamide drugs.
• Avoid using this medication if you have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Do not take this medication if you are breastfeeding, as it may pass into breast milk.

The side effects of Glimepiride 4mg Tablet may include:

• Hypoglycemia (low blood sugar)
• Dizziness or lightheadedness
• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea or constipation
• Headaches
• Skin rashes or itching
• Weight gain

Following are the precautions and warnings for Glimepiride 4mg Tablet:

• Patients with a known allergy to Glimepiride or other sulfonylurea drugs should not take this medication.
• Regular monitoring of blood glucose levels is essential, and adjustments in dosage may be required based on individual responses.
• Caution is advised in patients with kidney or liver disease, as the medication's metabolism can be affected.
• Elderly patients may be more susceptible to low blood sugar effects; dosage adjustments might be necessary.
• It may cause blurred vision, so patients should be cautious when driving or operating machinery.
• Alcohol consumption should be avoided or limited as it can affect blood sugar levels and increase the risk of hypoglycemia.
• Patients should be educated about the symptoms of hypoglycemia and hyperglycemia and the appropriate actions to take.
• Always inform your doctor about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Glimepiride 4mg Tablet:

• Sulfonamide antibiotics may increase the hypoglycemic effect, possibly requiring dose adjustments of glimepiride.
• Glimepiride's effect can be decreased by certain drugs like corticosteroids, diuretics, and sympathomimetics, which may necessitate increased glimepiride doses.
• When combined with beta-blockers, the warning signs of hypoglycemia may be masked, except for tremor.
• ACE inhibitors may enhance the blood-glimepiride level, potentially requiring glimepiride dose adjustments.
• Fluconazole, a potent CYP2C9 inhibitor, can increase glimepiride exposure, requiring careful monitoring for hypoglycemia.
• Glimepiride may increase the risk of hypoglycemia when used with other antidiabetic drugs, alcohol, MAO inhibitors, or salicylates.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can decrease the hypoglycemic effect, potentially requiring glimepiride dose adjustments.
• Caution is advised when using glimepiride with H2-receptor antagonists or proton pump inhibitors, as they may alter its absorption.

Following are the food interactions to consider with Glimepiride 4mg Tablet:

• Avoid excessive alcohol consumption as it can cause blood sugar fluctuations and may increase the risk of hypoglycemia, especially when combined with Glimepiride.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Glimepiride, potentially leading to increased drug levels and an elevated risk of hypoglycemia.
• Consuming a consistent and balanced diet is essential for maintaining stable blood sugar levels. Avoid excessive sugar intake and follow a diet plan recommended by your healthcare provider.
• High-fiber foods can slow down the absorption of Glimepiride, so consider taking the medication some time before or after consuming fiber-rich meals.
• Fatty meals may delay the absorption of Glimepiride, so it's best to take the medication either before or after such meals to ensure optimal absorption.
• Always monitor your blood sugar levels regularly, especially when making dietary changes, to ensure the medication's effectiveness and adjust dosages as needed.
• Some herbal supplements like ginseng and garlic may interact with Glimepiride, affecting blood sugar control. Consult your healthcare provider before taking any supplements.
• Maintain a healthy and consistent meal schedule to optimize the effectiveness of Glimepiride and manage your blood sugar levels effectively.

Glimepiride 4mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight and moisture. The original container should be used to keep the tablets protected from external factors, ensuring the cap is tightly secured after each use. It is crucial not to store the medication in hot environments like near a stove or inside a car to prevent degradation. Always pay attention to the expiration date on the packaging and never use medication beyond this date. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for advice on safe disposal methods. Lastly, keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Glimepiride 4mg Tablet:

• Take the tablet as directed by your doctor, typically once daily with breakfast or the first main meal.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent meal schedule, as food affects the medicine's absorption.
• Regularly monitor your blood sugar levels as advised by your doctor.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Do not stop taking the medication without consulting your doctor to prevent complications.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.

In order to track any abnormalities and ensure your body tolerates the medication properly, a complete blood count (CBC) will be performed to examine components of your blood such as red and white blood cells and platelets. A comprehensive metabolic panel (CMP) will likewise measure other important factors such as blood sugar, cholesterol, and kidney function. Given that diabetes commonly affects these levels, it is important to ensure the medication is not causing further negative effects on them. Maintaining these levels within a healthy range can help you avoid complications related to your diabetes and it is therefore important to discuss the results of these tests with your doctor to make sure your treatment plan is effective.