Clexane (80mg) 2 Pre-Filled Syringes

Enoxaparin, a low molecular weight heparin, exerts its therapeutic effects primarily through the inhibition of factor Xa. It preferentially binds to and activates antithrombin III, a natural anticoagulant in the body. This activation leads to the rapid inhibition of factor Xa, which is crucial in the coagulation cascade. By blocking the activity of factor Xa, enoxaparin effectively slows down the conversion of prothrombin to thrombin, thereby impeding the formation of fibrin clots. This mechanism helps prevent the development and growth of blood clots, making enoxaparin a valuable medication for the prevention and treatment of thromboembolic disorders.

Anticoagulant (Low Molecular Weight Heparin)

Syringe

The following are the uses of Enoxaparin Syringe:

• Used for preventing blood clots, especially after surgery or in conditions like deep vein thrombosis (DVT).
• Used for reducing the risk of blood clots in patients with certain medical conditions or during long periods of immobility.
• Used for treating existing blood clots in the lungs (pulmonary embolism) or legs (DVT).
• Used for managing unstable angina and heart attacks to prevent further clot formation.
• Used for preventing blood clots during pregnancy and postpartum for high-risk individuals.
• Used for maintaining the patency of indwelling central venous catheters.
• Used for anticoagulation in patients undergoing dialysis or with kidney problems.
• Used for preventing blood clots in patients with atrial fibrillation or after certain types of surgery.

In the case of an overdose of Enoxaparin Syringe, it is important to recognize the signs and act promptly. Symptoms may include excessive bleeding, easy bruising, and prolonged clotting times. If an overdose is suspected, seek medical advice immediately. Treatment involves closely monitoring the patient's coagulation parameters and providing supportive care. Prompt action and medical intervention are essential to manage potential complications effectively.

In the case of a missed dose of Enoxaparin Syringe, it is important to act promptly. If you realize you've missed a dose, administer it as soon as possible, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you frequently miss doses, inform your healthcare professional, as they may provide guidance on how to handle missed doses and ensure the medication's effectiveness.

To administer Enoxaparin Syringe, gently inject the prescribed dose subcutaneously, rotating injection sites as directed, and ensure you press the plunger slowly to control the flow and accuracy of the medication.

Here are the conditions or situations when Enoxaparin Syringe should not be used:

• Do not use if you have an active bleeding disorder or a high risk of bleeding complications.
• Contraindicated in patients with severe liver disease or liver failure.
• Avoid using if you have a known allergy to Enoxaparin or other low molecular weight heparins.
• Should not be used in patients with active or recent bleeding in the brain or spinal cord.
• Not recommended for patients with uncontrolled high blood pressure.
• Do not use if you have a history of heparin-induced thrombocytopenia (HIT) or heparin allergy.
• Contraindicated in patients with severe kidney disease requiring dialysis.
• Avoid using if you have had recent eye surgery or eye trauma.

The side effects of Enoxaparin Syringe may include:

• Easy bruising or bleeding (nosebleeds, bleeding gums)
• Mild skin irritation or rash at the injection site
• Unusual or excessive bleeding (from wounds, gums, nose, or menstrual bleeding)
• Thrombocytopenia (low platelet count)
• Headache or dizziness
• Nausea and vomiting
• Increased liver enzymes

Following are the precautions and warnings for Enoxaparin Syringe:

• Enoxaparin should be used with caution in patients with a history of bleeding disorders, as it can increase the risk of bleeding.
• Regular monitoring of blood clotting parameters is necessary during treatment, and adjustments may be required based on test results.
• Patients undergoing spinal anesthesia or spinal puncture procedures should inform their healthcare provider about Enoxaparin use to prevent potential spinal bleeding complications.
• It should be used with caution in the elderly, as they may be more prone to bleeding and require careful dosage adjustments.
• Patients with kidney problems should be monitored closely, as the dosage may need to be adjusted based on kidney function.
• Allergic reactions are possible; seek immediate medical attention if you experience symptoms like rash, itching, swelling, or difficulty breathing.
• Enoxaparin should be used during pregnancy and breastfeeding only if the potential benefits outweigh the risks, and under strict medical supervision.

Following are the drug interactions for Enoxaparin Syringe:

• Warfarin and other oral anticoagulants may increase the risk of bleeding when combined with Enoxaparin, so regular monitoring of coagulation is essential.
• Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen can further elevate bleeding risk.
• Thrombolytic agents, such as alteplase or reteplase, can potentiate the anticoagulant effect of Enoxaparin.
• Platelet aggregation inhibitors (e.g., clopidogrel, prasugrel) may enhance the antiplatelet activity of Enoxaparin.
• Certain antibiotics like glycopeptides (e.g., vancomycin) and aminoglycosides (e.g., gentamicin) may increase bleeding risk.
• Drugs that elevate international normalized ratio (INR), including some antifungals (e.g., voriconazole) and antibiotics (e.g., metronidazole), require careful monitoring.
• The use of Enoxaparin with other parenteral anticoagulants should be done cautiously due to the potential for additive effects.

Following are the food interactions to be aware of when using Enoxaparin Syringe:

• Avoid excessive alcohol consumption as it can increase the risk of bleeding complications when combined with Enoxaparin.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the medication's metabolism, potentially altering its effectiveness.
• Foods rich in vitamin K, like leafy green vegetables, broccoli, and liver, can impact the anticoagulant effect of Enoxaparin, and their intake should be consistent to maintain stable blood clotting times.
• High-fat meals might affect the absorption of Enoxaparin, so it's best to use the medication consistently with regards to meal timing.
• Avoid cranberry juice as it may decrease the effectiveness of Enoxaparin by influencing the enzyme CYP3A4.
• Limit fish oil supplements as they can enhance the anticoagulant effect, increasing the risk of bleeding.
• Consult your healthcare provider for specific dietary recommendations, especially if you have dietary restrictions or preferences.

Enoxaparin Syringe storage and disposal requires careful attention to ensure safety and environmental responsibility. Store the syringe at room temperature, away from excessive heat, direct sunlight, and moisture. Keep it in its original packaging, tightly sealed, to maintain its integrity and protect it from contamination. It is crucial not to freeze the medication. Always check the expiration date, and if the syringe is expired or no longer needed, do not dispose of it in regular trash or flush it down the toilet. Contact your local waste management authorities or healthcare provider for instructions on proper disposal methods to prevent harm to the environment and ensure the safe handling of medical waste. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Enoxaparin Syringe:

• Wash your hands thoroughly before and after handling the syringe for cleanliness.
• Ensure you understand the correct injection technique; your healthcare provider can guide you.
• Administer the injection as prescribed, usually twice daily, at the same time each day.
• Gently swirl the syringe to mix the medication; do not shake vigorously.
• Clean the injection site with an alcohol swab before inserting the needle.
• Dispose of used syringes in a puncture-proof container, keeping it out of reach of children.
• Inform your doctor if you experience any unusual bruising or bleeding during treatment.